Richard Eckner

former START fellow

is now Associate Professor at the University of New Jersey, Newark, USA

Institut für Molekularbiologie
Universität Zürich
Winterthurerstrasse 190
8057 Zürich
Schweiz

++41-1-635-3160 (office)
++41-1-635-3161 (lab)
++41-1-635-6811 (fax, institute)

eckner@molbio.unizh.ch

new address:

 University of Medicine and Dentristy New Jersey
 Dept. of Cell Biology & Molecular Medicine - G661
 185 South Orange Ave.
 Newark, NJ 07101-1709
 USA


 phone +1 (973) 972 5376 (office)
          +1 (973) 972 0822 (lab)
 fax     +1 (973) 972 7489
 e-mail: ecknerrc@umdnj.edu

 
Research

Our laboratory studies two large nuclear proteins named p300 and CBP. Both bind to the adenovirus E1A and SV40 large T antigen oncoproteins. This interaction appears to be essential for the growth stimulatory functions of these two oncoproteins. Based on such results, p300 and CBP seem to be intimately involved in cellular growth and differentiation pathways. In keeping with this view, several types of human cancer exhibit deregulated p300 and CBP function.
Current experiments using mouse and tissue culture systems are aimed at elucidating and understanding the role of these two proteins in growth control and cellular differentiation.

Recent publications

Shikama N, Lutz W, Kretzschmar R, Sauter N, Roth JF, Marino S, Wittwer J, Scheidweiler A and Eckner R (2003) "Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation." Embo J 22(19):5175-5185 Abstract

Roth JF, Shikama N, Henzen C, Desbaillets I, Lutz W, Marino S, Wittwer J, Schorle H, Gassmann M and Eckner R (2003) "Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5." Embo J 22(19):5186-5196 Abstract

Bordoli, L., Hüsser, S., Lüthi, U., Netsch, M., Osmani, H., and Eckner, R. (2001) Functional analysis of the p300 acetyltransferase domain: the PHD finger of p300 but not of CBP is dispensable for enzymatic activity. Nucleic Acids Res. 29: 4462-4471. Abstract

Bordoli, L., Netsch, M., Lüthi, U., Lutz, W. and Eckner, R. (2001). Plant orthologs of p300/CBP: conservation of a core domain in metazoan p300/CBP acetyltransferase-related proteins. Nucleic Acids Res. 29, 589-597. Abstract

Yao, T.-P. Oh, S.P., Fuchs, M., Zhou, N-D., Ch'ng, L.-E., Newsome, D., Bronson, R., Li, E., Livingston, D.M., and Eckner, R. (1998). Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell 93, 361-372. Abstract

Kawasaki, H., Eckner, R., Yao,T.-P., Taira, K., Chiu, R., Livingston, D.M., and Yokoyama, K.K. (1998). Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation. Nature 393, 284-289. Abstract

Eckner, R. (1996). p300 and CBP as transcriptional regulators and targets of oncogenic events. Biol. Chem. 377, 685-688. Abstract

Eckner, R., Yao, T.-P., Oldread, E. and Livingston, D. M. (1996). Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. Genes Dev. 10, 2478-2490. Abstract

Bhattacharya, S., Eckner, R., Grossman, S., Oldread, E., Arany, Z., D'Andrea, A. and Livingston, D. M. (1996). Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha. Nature 383, 344-347. Abstract

Eckner, R., Ludlow, J.W., Lill, N.L., Oldread, E., Arany, Z., Modjtahedi, N., DeCaprio, J.A., Livingston, D.M., and Morgan, J.A. (1996). Association of p300 and CBP with simian virus 40 large T antigen. Mol. Cell. Biol. 16, 3454-3464. Abstract

Arany, Z., Newsome, D., Oldread, E., Livingston, D. M. and Eckner, R. (1995). A family of transcriptional adaptor proteins targeted by the E1A oncoprotein. Nature 374, 81-4. Abstract

Arany, Z., Sellers, W. R., Livingston, D. M. and Eckner, R. (1994). E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators [letter]. Cell 77, 799-800. Abstract

Eckner, R., Ewen, M. E., Newsome, D., Gerdes, M., DeCaprio, J. A., Lawrence, J. B. and Livingston, D. M. (1994). Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev. 8, 869-84. Abstract, GenBank: U01877, PIR:A54277